C–O-Selective Cross-Coupling of Chlorinated Phenol Derivatives

Abstract Chemoselective cross-coupling of phenol derivatives is valuable for generating products that retain halides. Here we discuss recent developments in selective cross-couplings chloroaryl derivatives, with a particular focus on reactions tosylates. The first example C–O-selective Ni-catalyzed Suzuki–Miyaura coupling tosylates discussed detail. 1 Introduction 2 Density Functional Theory Studies Oxidative Addition at Nickel(0) 3 Stoichiometric 4 Development Tosylate-Selective Suzuki Coupling 5 Conclusion and Outlook